Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

@article{Simon2010ModulationOF,
  title={Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed},
  author={Michael A. Simon and Aiguo Xu and Hiroyuki Ishikawa and Kenneth D Irvine},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={811-817}
}
In addition to quantitative differences in morphogen signaling specifying cell fates, the vector and slope of morphogen gradients influence planar cell polarity (PCP) and growth. The cadherin Fat plays a central role in this process. Fat regulates PCP and growth through distinct downstream pathways, each involving the establishment of molecular polarity within cells. Fat is regulated by the cadherin Dachsous (Ds) and the protein kinase Four-jointed (Fj), which are expressed in gradients in many… CONTINUE READING

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