Modulation of Fas-mediated apoptosis of human thyroid epithelial cells by IgG from patients with Graves' disease (GD) and idiopathic myxoedema.

@article{Kawakami1997ModulationOF,
  title={Modulation of Fas-mediated apoptosis of human thyroid epithelial cells by IgG from patients with Graves' disease (GD) and idiopathic myxoedema.},
  author={Akinori Kawakami and Katsumi Eguchi and Naoki Matsuoka and Masahiko Tsuboi and Satoshi Urayama and Yojiro Kawabe and Kazuki Tahara and Nobuhisa Ishikawa and Koichi Ito and Shigenobu Nagataki},
  journal={Clinical and experimental immunology},
  year={1997},
  volume={110 3},
  pages={434-9}
}
The expression of two autoimmune thyroid diseases. GD and idiopathic myxoedema, is associated with antibodies to the thyroid-stimulating hormone (TSH) receptor. Thyroid stimulating antibodies (TSAb) in GD are TSH agonists and cause hyperthyroidism as well as goitre, whereas thyroid stimulation blocking antibodies (TSBAb) in idiopathic myxoedema are TSH antagonists and cause hypothyroidism and thyroid atrophy. We investigated the effect of antibodies to TSH receptor on Fas-mediated apoptosis of… CONTINUE READING
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