Modulation of DNA synthesis in cultured muscle cells by 1,25-dihydroxyvitamin D-3.

@article{Drittanti1989ModulationOD,
  title={Modulation of DNA synthesis in cultured muscle cells by 1,25-dihydroxyvitamin D-3.},
  author={L N Drittanti and Ana Russo de Boland and Ricardo L. Boland},
  journal={Biochimica et biophysica acta},
  year={1989},
  volume={1014 2},
  pages={112-9}
}
Biphasic effects of 1,25-dihydroxyvitamin D-3 on DNA synthesis were shown in primary cultured (24 h) chick embryo myoblasts exposed to physiological concentrations of the hormone. The sterol stimulated [3H]thymidine incorporation into DNA in proliferating myoblasts, e.g., at early stages of culture prior to cell fusion or in high serum-treated cells. The opposite effects were observed during the subsequent stage of myoblast differentiation in low-serum media. The mitogenic effect of 1,25… CONTINUE READING