Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

@article{Liu2009ModulationOD,
  title={Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide},
  author={Z. Liu and Shujun Liu and Zhiliang Xie and R. Pavlovicz and Jiejun Wu and Ping Chen and J. Aimiuwu and J. Pang and D. Bhasin and P. Neviani and J. Fuchs and C. Plass and Pui-kai Li and C. Li and T. Huang and Lai-Chu Wu and L. Rush and Hongyang Wang and D. Perrotti and G. Marcucci and Kenneth K. Chan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2009},
  volume={329},
  pages={505 - 514}
}
Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA methylation with DNA methylation inhibitors has been shown to result in cancer cell differentiation or apoptosis and represents a novel strategy for chemotherapy. Currently, effective DNA methylation inhibitors are mainly limited to decitabine and 5-azacytidine, which still show unfavorable toxicity profiles in the… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.
Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
Procainamide Is a Specific Inhibitor of DNA Methyltransferase 1*
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies.
  • F. Lyko, R. Brown
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 2005
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy.
...
1
2
3
4
5
...