Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase.

@article{Dumin2006ModulationOD,
  title={Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase.},
  author={Elena Dumin and Inna Bendikov and Veronika N Foltyn and Yoshio Misumi and Yukio Ikehara and Elena Kartvelishvily and Herman Wolosker},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={
          20291-302
        }
}
Mammalian serine racemase is a brain-enriched enzyme that converts L- into D-serine in the nervous system. D-Serine is an endogenous co-agonist at the "glycine site" of N-methyl D-aspartate (NMDA) receptors that is required for the receptor/channel opening. Factors regulating the synthesis of D-serine have implications for the NMDA receptor transmission, but little is known on the signals and events affecting serine racemase levels. We found that serine racemase interacts with the Golgin… CONTINUE READING

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