Modulation of Cl- secretion in rat distal colon by genistein, a protein tyrosine kinase inhibitor.

@article{Diener1996ModulationOC,
  title={Modulation of Cl- secretion in rat distal colon by genistein, a protein tyrosine kinase inhibitor.},
  author={Martin Diener and F. Hug},
  journal={European journal of pharmacology},
  year={1996},
  volume={299 1-3},
  pages={161-70}
}
The protein tyrosine kinase inhibitor, genistein, caused an increase of short-circuit current (Isc) across the rat distal colon in forskolin-pretreated tissues, suggesting a synergistic interaction of the drug with cAMP-dependent secretion. In the absence of forskolin, genistein had a dual effect on Isc, it increased Isc in tissues with a low baseline, but decreased Isc in tissues with a high baseline Isc. The secretory effect of genistein was dependent on the presence of Cl- and was blocked by… CONTINUE READING

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