Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

  title={Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol},
  author={Bodhisattwa Mondal and Hongxia Chen and Weihua Wen and Ercole L Cavalieri and Eleanor G. Rogan and Muhammad Zahid},
  journal={ACS Omega},
  pages={5511 - 5515}
Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3… 

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