Modulation of Cellular Proliferation Alters Glutamine Transport and Metabolism in Human Hepatoma Cells

  title={Modulation of Cellular Proliferation Alters Glutamine Transport and Metabolism in Human Hepatoma Cells},
  author={B. Bode and W. Souba},
  journal={Annals of Surgery},
OBJECTIVE The authors determined the effects of growth inhibition on glutamine transport and metabolism in human hepatoma cells. SUMMARY BACKGROUND DATA Hepatoma cells exhibit markedly higher (10- to 30-fold) glutamine uptake than normal human hepatocytes, via a disparate transporter protein with a higher affinity for glutamine. Currently, little is known about the effects of growth arrest on glutamine transport and metabolism in hepatoma cells. METHODS The authors determined proliferation… Expand
Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells.
  • B. Bode, B. Fuchs, +6 authors W. Souba
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2002
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  • B. Bode, W. Souba
  • Biology, Medicine
  • JPEN. Journal of parenteral and enteral nutrition
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A new and improved preparation of hyperpolarized [5-(13)C]glutamine is reported, which provides a highly sensitive ( 13)C MR marker, which was investigated in vivo in a rat liver tumour and was used to measure response to drug treatment in vitro in cancer cells. Expand