Modulation of Cell Signaling Networks after CTLA4 Blockade in Patients with Metastatic Melanoma

@inproceedings{CominAnduix2010ModulationOC,
  title={Modulation of Cell Signaling Networks after CTLA4 Blockade in Patients with Metastatic Melanoma},
  author={Begonya Comin-Anduix and Hooman Sazegar and Thinle Chodon and Douglas R Matsunaga and Jason Jalil and Erika Mar{\'i}a von Euw and Helena Escuin-Ordinas and Robert Balderas and Bartosz Chmielowski and Jes{\'u}s G{\'o}mez-Navarro and Richard Chikara Koya and Antoni Ribas},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The effects on cell signalling networks upon blockade of cytotoxic T lymphocyte-associated antigen-4 (CTLA4) using the monoclonal antibody tremelimumab were studied in peripheral blood mononuclear cell (PBMC) samples from patients with metastatic melanoma. METHODOLOGY/PRINCIPAL Findings Intracellular flow cytometry was used to detect phosphorylated (p) signaling molecules downstream of the T cell receptor (TCR) and cytokine receptors. PBMC from tremelimumab-treated patients were… CONTINUE READING
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Biomarkers on melanoma patient T Cells associated with ipilimumab treatment

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CTLA4 blockade broadens the peripheral T-cell receptor repertoire.

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