Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis

@article{Ullah2001ModulationOC,
  title={Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis},
  author={Hemayet Ullah and J G Chen and J. C. Young and Kyung Hoan Im and Michael R. Sussman and A. M. Jones},
  journal={Science},
  year={2001},
  volume={292},
  pages={2066 - 2069}
}
The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall… 
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A method is described here to quantify cell division and cell elongation in the Arabidopsis heterotrimeric G-protein mutants using the hypocotyl as a model system.
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The role of G-proteins in cell division has been best characterized in hypocotyls, rosette leaves, and roots, and little is known about the upstream and downstream components coupled to G-protein complex in the regulation of cell division.
Differential Roles of Arabidopsis Heterotrimeric G-Protein Subunits in Modulating Cell Division in Roots1[W]
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It is found in the RAM that the heterotrimeric complex acts as an attenuator of cell proliferation, whereas the GTP-bound form of the Gα-subunit's role is a positive modulator, and for the formation of lateral roots, the Gβγ-dimer acts largely independently of theGα- subunit to attenuate cell division.
A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation
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An RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity is identified, suggesting that AtRGS 1 is a critical modulator of plant cell proliferation.
Heterotrimeric G-Protein Signaling in Plants
  • S. Pandey
  • Biology
    Sensory Biology of Plants
  • 2019
Heterotrimeric GTP-binding proteins comprised of Gα, Gβ, and Gγ subunits are key regulators of a multitude of signaling pathways in all eukaryotes. In plants, these proteins are currently a focus of…
Role of the plant heterotrimeric G-proteins in the signal pathways regulation
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This review is devoted to the analysis of modern ideas about the structure and functioning of heterotrimeric plant G proteins.
Arabidopsis MCM2 is responsible for reduction in cell division induced by loss of function of the alpha subunit of GTP-binding protein
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Results indicate that reduction in AtMCM2 gene is responsible for the reduction in hypocotyl cell division induced by loss of function of the alpha subunit of GTP-binding protein.
Function of Heterotrimeric G Protein in Gibberellin Signaling
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The possible functions of rice heterotrimeric G proteins in gibberellin signaling are discussed here and suggest that these proteins are involved in several intra-signaling pathways driven by external signals.
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