Modulation of Ca2+ signalling in rat atrial myocytes: possible role of the alpha1C carboxyl terminal.

@article{Woo2003ModulationOC,
  title={Modulation of Ca2+ signalling in rat atrial myocytes: possible role of the alpha1C carboxyl terminal.},
  author={S H Woo and Nikolai M. Soldatov and Martin Morad},
  journal={The Journal of physiology},
  year={2003},
  volume={552 Pt 2},
  pages={437-47}
}
Ca2+ influx through L-type Cav1.2 (alpha1C) Ca2+ channels is a critical step in the activation of cardiac ryanodine receptors (RyRs) and release of Ca2+ via Ca2+-induced Ca2+ release(CICR). The released Ca2+, in turn, is the dominant determinant of inactivation of the Ca2+ current (ICa) and termination of release. Although Ca2+ cross-signalling is mediated by high Ca2+ fluxes in the microdomains of alpha1C-RyR complexes, ICa-gated Ca2+ cross-signalling is surprisingly resistant to intracellular… CONTINUE READING