Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors.

  title={Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors.},
  author={David I. Yule and Stephen V. Straub and Jason I. E. Bruce},
  journal={Biochemical Society transactions},
  volume={31 Pt 5},
Activation of InsP(3)Rs (InsP(3) receptors) represents the major mechanism underlying intracellular calcium release in non-excitable cells such as hepatocytes and exocrine cells from the pancreas and salivary glands. Modulation of calcium release through InsP(3)Rs is therefore a major route whereby the temporal and spatial characteristics of calcium waves and oscillations can potentially be 'shaped'. In this study, the functional consequences of phosphoregulation of InsP(3)Rs were investigated… CONTINUE READING

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