Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells.

@article{Cheng1999ModulationOC,
  title={Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells.},
  author={Hi-shan Cheng and Weng Sie Wong and Keefe T. Chan and Xiao Fei Wang and Z. D. Wang and H. C. Chan},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1418 1},
  pages={31-8}
}
The study investigated the role of protein kinase C (PKC) in the modulation of agonist-induced Ca2+-dependent anion secretion by pancreatic duct cells. The short-circuit current (ISC) technique was used to examine the effect of PKC activation and inhibition on subsequent ATP, angiotensin II and ionomycin-activated anion secretion by normal (CAPAN-1) and cystic fibrosis (CFPAC-1) pancreatic duct cells. The ISC responses induced by the Ca2+-mobilizing agents, which had been previously shown to be… CONTINUE READING