Modulation of Ca2+-activated K+ channels in human vascular cells by insulin and basic fibroblast growth factor.

@article{Wiecha1998ModulationOC,
  title={Modulation of Ca2+-activated K+ channels in human vascular cells by insulin and basic fibroblast growth factor.},
  author={Johannes Wiecha and K Reineker and M Reitmayer and Rainer Voisard and Andreas Hannekum and Torsten Mattfeldt and Johannes Waltenberger and V. Hombach},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={1998},
  volume={8 2},
  pages={175-81}
}
Insulin and basic fibroblast growth factor (bFGF) play an important role in the pathogenesis of atherosclerosis and have been shown to have vasodilatory effects. Since modulation of vascular ion channels determines membrane potential and thereby influences essential Ca2+-dependent intracellular pathways, we have investigated the effect of insulin and bFGF on Ca2+-activated K+ channels (BKCa) in human umbilical vein endothelial cells (HUVEC) and smooth muscle cells. The latter were obtained from… CONTINUE READING