Modulation of Ca currents in isolated frog atrial cells studied with photosensitive probes. Regulation by cAMP and Ca2+: a common pathway?

@article{Charnet1991ModulationOC,
  title={Modulation of Ca currents in isolated frog atrial cells studied with photosensitive probes. Regulation by cAMP and Ca2+: a common pathway?},
  author={Pierre Charnet and Sylvain Richard and Alison M Gurney and H. Ouadid and François Tiaho and Jo{\"e}l Nargeot},
  journal={Journal of molecular and cellular cardiology},
  year={1991},
  volume={23 3},
  pages={
          343-56
        }
}
We have studied the regulation of cardiac Ca current by intracellular cyclic AMP (cAMP) and Ca2+, using photosensitive, caged compounds and the whole-cell, patch-clamp technique in isolated frog atrial cells. Although both low voltage activated (LVA) and high voltage activated (HVA) Ca channels were found to be present in these cells, only the HVA Ca currents were sensitive to modulation by isoproterenol or dihydropyridines (DHPs). The application of extracellular isoproterenol, as well as the… CONTINUE READING
BETA

Similar Papers

Loading similar papers…