Modulation of CYPs, P-gp, and PXR by Eschscholzia californica (California Poppy) and Its Alkaloids.

@article{Manda2016ModulationOC,
  title={Modulation of CYPs, P-gp, and PXR by Eschscholzia californica (California Poppy) and Its Alkaloids.},
  author={Vamshi K Manda and Mohamed Ali Ibrahim and Olivia Reed Dale and Mallika Kumarihamy and Stephen J. Cutler and Ikhlas A. Khan and Larry A Walker and Ilias Muhammad and Shabana I. Khan},
  journal={Planta medica},
  year={2016},
  volume={82 6},
  pages={
          551-8
        }
}
Eschscholzia californica, a native US plant, is traditionally used as a sedative, analgesic, and anxiolytic herb. With the rapid rise in the use of herbal supplements together with over-the-counter and prescription drugs, the risk for potential herb-drug interactions is also increasing. Most of the clinically relevant pharmacokinetic drug interactions occur due to modulation of cytochrome P450 enzymes (CYPs), P-glycoprotein, and the pregnane X receptor by concomitantly used herbs. This study… 
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