Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.

@article{Rajaraman2009ModulationOC,
  title={Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.},
  author={Ganesh Rajaraman and Guixiang Yang and Jie Chen and Thomas K. H. Chang},
  journal={Canadian journal of physiology and pharmacology},
  year={2009},
  volume={87 9},
  pages={
          674-83
        }
}
The aryl hydrocarbon receptor (AhR) signaling pathway regulates the production of CYP1B1 and CYP1A1, which catalyze the bioactivation of various procarcinogens. In the present study, we investigated the effect of Ginkgo biloba extract and some of its chemical constituents on CYP1B1 and CYP1A1 gene expression and AhR activity in cultured MCF-10A human mammary epithelial cells. Treatment of MCF-10A cells with noncytotoxic concentrations of G. biloba extract (25-300 microg/mL for 24 or 48 h… CONTINUE READING
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CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Antiestrogenic activities of Ginkgo biloba extracts

  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2006
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

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