Modulation of CRF-R1 mRNA in rat anterior pituitary by dexamethasone: correlation with POMC mRNA.

@article{Zhou1996ModulationOC,
  title={Modulation of CRF-R1 mRNA in rat anterior pituitary by dexamethasone: correlation with POMC mRNA.},
  author={Yan Zhou and Rudolph Spangler and K Steven Laforge and Christopher E Maggos and A. -S. Ho and Mary Jeanne Kreek},
  journal={Peptides},
  year={1996},
  volume={17 3},
  pages={435-41}
}
Glucocorticoids have been shown to decrease CRF receptor binding in the anterior pituitary. To determine whether glucocorticoids or CRF peptide modulate CRF-R1 gene expression, CRF-R1 mRNA levels in rat pituitary and brain were measured after administration of a synthetic glucocorticoid, dexamethasone (DEX) or rat/human CRF (r/hCRF), using a sensitive solution hybridization RNase protection assay. DEX (400 micrograms/day) or r/hCRF (100 micrograms/kg/day) was administered twice daily for 5 days… CONTINUE READING
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