Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.

@article{Manji1999ModulationOC,
  title={Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.},
  author={Husseini K. Manji and Joseph M Bebchuk and Gregory J. Moore and Debra A Glitz and K A Hasanat and Guang Chen},
  journal={The Journal of clinical psychiatry},
  year={1999},
  volume={60 Suppl 2},
  pages={27-39; discussion 40-1, 113-6}
}
In an attempt to find the key to reducing the excessive morbidity and mortality seen with mood disorders, our laboratory has been extensively investigating lithium's mechanisms of action in an integrated series of clinical and preclinical studies. We have found that the chronic administration of the 2 structurally highly dissimilar agents, lithium and valproate, brings about a strikingly similar reduction in protein kinase C (PKC) alpha and epsilon isozymes in rat frontal cortex and hippocampus… CONTINUE READING

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