Modulation of CD46 in T cells

  title={Modulation of CD46 in T cells},
  author={Laurie A. Dempsey},
  journal={Nature Immunology},
CD14 acts as a co-factor for the Toll-like receptor TLR4 to activate inflammatory responses to lipopolysaccharides. In Immunity, Zanoni et al. report that CD14 recognizes host-derived inflammatory lipids composed of oxidized phosphrylcholine derivatives released from dying cells. Such recognition triggers transient down-regulation of CD14 from the cell surface and cytosolic caspase-11-dependent activation of the inflammasome, independently of TLR4 responses. Exposure to oxidized… CONTINUE READING