Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women.

@article{Fabian2015ModulationOB,
  title={Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women.},
  author={Carol J. Fabian and Bruce F Kimler and Teresa A. Phillips and Jennifer L. Nydegger and Amy L Kreutzjans and Susan E. Carlson and Brandon H. Hidaka and Trina Metheny and Carola M. Zalles and Gordon B. Mills and Kandy R Powers and Debra K. Sullivan and Brian K. Petroff and Whitney L Hensing and Brooke L. Fridley and Stephen D. Hursting},
  journal={Cancer prevention research},
  year={2015},
  volume={8 10},
  pages={922-31}
}
Associational studies suggest higher intakes/blood levels of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to the omega-6 arachidonic acid (AA) are associated with reduced breast cancer risk. We performed a pilot study of high-dose EPA + DHA in postmenopausal women to assess feasibility before initiating a phase IIB prevention trial. Postmenopausal women with cytologic evidence of hyperplasia in their baseline random periareolar fine needle… CONTINUE READING
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