Modulation of Bleomycin-Induced Lung Fibrosis by Pegylated Hyaluronidase and Dopamine Receptor Antagonist in Mice

@inproceedings{Skurikhin2015ModulationOB,
  title={Modulation of Bleomycin-Induced Lung Fibrosis by Pegylated Hyaluronidase and Dopamine Receptor Antagonist in Mice},
  author={Evgenii Germanovich Skurikhin and Olga Victorovna Pershina and Alena Mikhaylovna Reztsova and Natalia Nikolaevna Ermakova and Ekaterina Sergeevna Khmelevskaya and Vycheslav Andreevich Krupin and Inna Ernestovna Stepanova and Andrew Vladimirovich Artamonov and Andrew Alexandrovich Bekarev and Pavel Gennadjevich Madonov and Alexander Mikhaylovich Dygai},
  booktitle={PloS one},
  year={2015}
}
Hyaluronidases are groups of enzymes that degrade hyaluronic acid (HA). To stop enzymatic hydrolysis we modified testicular hyaluronidase (HYAL) by activated polyethylene oxide with the help of electron-beam synthesis. As a result we received pegylated hyaluronidase (pegHYAL). Spiperone is a selective D2 dopamine receptor antagonist. It was demonstrated on the model of a single bleomycin damage of alveolar epithelium that during the inflammatory phase monotherapy by pegHYAL or spiperone reduced… CONTINUE READING
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