Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists.

@article{Wagner2002ModulationOB,
  title={Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists.},
  author={Daniel S Wagner and Mary C Mullins},
  journal={Developmental biology},
  year={2002},
  volume={245 1},
  pages={109-23}
}
We analyzed the interactions between mutations in antagonistic BMP pathway signaling components to examine the roles that the antagonists play in regulating BMP signaling activity. The dorsalized mutants swirl/bmp2b, snailhouse/bmp7, lost-a-fin/alk8, and mini fin/tolloid were each analyzed in double mutant combinations with the ventralized mutants chordino/chordin and ogon, whose molecular nature is not known. Similar to the BMP antagonist chordino, we found that the BMP ligand mutants swirl… CONTINUE READING

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