Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.

@article{Clarke2002ModulationOB,
  title={Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.},
  author={Alison L. Clarke and Steven Petrou and John V. Walsh and Joshua A. Singer},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 5},
  pages={C1441-53}
}
To determine the mechanism of fatty acid modulation of rabbit pulmonary artery large-conductance Ca2+ -activated K+ (BK(Ca)) channel activity, we studied effects of fatty acids and other lipids on channel activity in excised patches with patch-clamp techniques. The structural features of the fatty acid required to increase BK(Ca) channel activity (or average number of open channels, NP(o)) were identified to be the negatively charged head group and a sufficiently long (C > 8) carbon chain… CONTINUE READING

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