Modulation of BDNF and TrkB expression in rat hippocampus in response to acute neurotoxicity by diethyldithiocarbamate.

@article{Micheli2006ModulationOB,
  title={Modulation of BDNF and TrkB expression in rat hippocampus in response to acute neurotoxicity by diethyldithiocarbamate.},
  author={Maria Rita Micheli and RonaldoJ. Bova and Maria Assunta Laurenzi and Moira Bazzucchi and Gigliola Grassi Zucconi},
  journal={Neuroscience letters},
  year={2006},
  volume={410 1},
  pages={66-70}
}
In this study, we examined the expression profile of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in adult rat hippocampus following acute administration of diethyldithiocarbamate (DDTC), a neurotoxic compound which was previously shown to induce microglia activation and cell death. Semiquantitative RT-PCR analysis detected significant… CONTINUE READING