Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR

@article{Zhang2002ModulationOA,
  title={Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR},
  author={J. Zhang and W. Huang and S. Chua and P. Wei and D. Moore},
  journal={Science},
  year={2002},
  volume={298},
  pages={422 - 424}
}
We have identified the xenobiotic receptor CAR (constitutive androstane receptor) as a key regulator of acetaminophen metabolism and hepatotoxicity. Known CAR activators as well as high doses of acetaminophen induced expression of three acetaminophen-metabolizing enzymes in wild-type but not in CAR null mice, and the CAR null mice were resistant to acetaminophen toxicity. Inhibition of CAR activity by administration of the inverse agonist ligand androstanol 1 hour after acetaminophen treatment… Expand
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