Modulation of ATP-sensitive potassium channels by cGMP-dependent protein kinase in rabbit ventricular myocytes.

Abstract

This investigation used a patch clamp technique to test the hypothesis that protein kinase G (PKG) contributes to the phosphorylation and activation of ATP-sensitive K(+) (K(ATP)) channels in rabbit ventricular myocytes. Nitric oxide donors and PKG activators facilitated pinacidil-induced K(ATP) channel activities in a concentration-dependent manner, and a… (More)

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Cite this paper

@article{Han2001ModulationOA, title={Modulation of ATP-sensitive potassium channels by cGMP-dependent protein kinase in rabbit ventricular myocytes.}, author={J. Han and N. Kim and E. Kim and W. K. Ho and Yung E. Earm}, journal={The Journal of biological chemistry}, year={2001}, volume={276 25}, pages={22140-7} }