Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

@article{Shen2002ModulationOA,
  title={Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates},
  author={Xuetong Shen and Hua Xiao and Ryan T. Ranallo and Wei-Hua Wu and Carl Wu},
  journal={Science},
  year={2002},
  volume={299},
  pages={112 - 114}
}
Eukaryotes use adenosine triphosphate (ATP)–dependent chromatin-remodeling complexes to regulate gene expression. Here, we show that inositol polyphosphates can modulate the activities of several chromatin-remodeling complexes in vitro. Inositol hexakisphosphate (IP6) inhibits nucleosome mobilization by NURF, ISW2, and INO80 complexes. In contrast, nucleosome mobilization by the yeast SWI/SNF complex is stimulated by inositol tetrakisphosphate (IP4) and inositol pentakisphosphate (IP5). We… 

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