Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema.

@article{Taya2008ModulationOA,
  title={Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema.},
  author={Keisuke Taya and Salih Gulsen and Kenji Okuno and Ruth Prieto and Christina R Marmarou and Anthony Marmarou},
  journal={Acta neurochirurgica. Supplement},
  year={2008},
  volume={102},
  pages={425-9}
}
BACKGROUND Currently, there are no pharmacological treatments available for traumatically induced brain edema and the subsequent rise of ICP. Evidence indicates that Aquaporin-4 (AQP4) plays a significant role in the pathophysiology of brain edema. Previously we have reported that SR49059 reduced brain edema secondary to ischemia. We, therefore, examined whether the selective V1a receptor antagonist, SR49059, reduces brain edema by modulating AQP4 expression following cortical contusion injury… CONTINUE READING