Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products.

@article{Hagmeyer1995ModulationOA,
  title={Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products.},
  author={B M Hagmeyer and Peter Angel and Hans van Dam},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1995},
  volume={17 7},
  pages={621-9}
}
The proteins encoded by early region 1 A (E1A) of human adenoviruses (Ad) modulate the expression of both adenovirus genes and various host cell genes. With these transcription-regulating properties the E1A proteins redirect the cell's metabolism, which enables them to induce oncogenic transformation in rodent cells. The E1A proteins modulate transcription by interacting both with gene-specific and general cellular transcription factors. Various members of the AP-1 and ATF/CREB families of… CONTINUE READING
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