Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

@article{Spicarova2010ModulationOA,
  title={Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.},
  author={Diana Spicarova and Jiri Palecek},
  journal={Neuroscience},
  year={2010},
  volume={166 1},
  pages={305-11}
}
Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to be expressed on spinal cord DH neurons, but their possible role in sensory transmission has not been studied. In this work the effect of insulin application on fast excitatory postsynaptic currents (EPSCs) mediated by AMPA… CONTINUE READING
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