Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.

@article{Loane2011ModulationOA,
  title={Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.},
  author={David J. Loane and Patricia M. Washington and Lilit Vardanian and Ana Pocivavsek and Hyang-Sook Hoe and Karen E Duff and Ibolja Cernak and George William Rebeck and Alan I. Faden and Mark P Burns},
  journal={Journal of neurotrauma},
  year={2011},
  volume={28 2},
  pages={225-36}
}
Traumatic brain injury (TBI) increases brain beta-amyloid (Aβ) in humans and animals. Although the role of Aβ in the injury cascade is unknown, multiple preclinical studies have demonstrated a correlation between reduced Aβ and improved outcome. Therefore, therapeutic strategies that enhance Aβ clearance may be beneficial after TBI. Increased levels of ATP-binding cassette A1 (ABCA1) transporters can enhance Aβ clearance through an apolipoprotein E (apoE)-mediated pathway. By measuring Aβ and… CONTINUE READING
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