Modulation of 5HT1A receptors in the hippocampus and the raphe area of rats treated with clonazepam.

@article{Lima1993ModulationO5,
  title={Modulation of 5HT1A receptors in the hippocampus and the raphe area of rats treated with clonazepam.},
  author={Lucimey Lima and Mario Salazar and Ernesto Trejo},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={1993},
  volume={17 4},
  pages={663-77}
}
1. Clonazepam is one of the most potent benzodiazepines known to decrease the activity of the central serotonergic systems. The acute and subchronic administration of clonazepam reduced serotonin (5HT) turnover rate in the hippocampus of the rat, as determined by the ratio of the monoamine and its metabolite, 5-hydroxyindoleacetic acid. 2. The modulation of 5HT binding sites and 5HT1A receptors by the administration of clonazepam for various periods of time were studied in the hippocampus and… CONTINUE READING