Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin.

@article{Sbrenna2000ModulationO5,
  title={Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin.},
  author={S Sbrenna and Matteo Marti and Michele Morari and Girolamo Calo' and Remo Guerrini and Lorenzo Beani and Clementina Bianchi},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 2},
  pages={425-33}
}
The modulation of [(3)H]-5-hydroxytryptamine ([(3)H]-5-HT) efflux from superfused rat cortical synaptosomes by delta, kappa, mu and ORL(1) opioid receptor agonists and antagonists was studied. Spontaneous [(3)H]-5-HT efflux was reduced (20% inhibition) by either 0.5 microM tetrodotoxin or Ca(2+)-omission. Ten mM K(+)-evoked [(3)H]-5-HT overflow was largely Ca(2+)-dependent (90%) and tetrodotoxin-sensitive (50%). The delta receptor agonist, deltorphin-I, failed to modulate the K(+)-evoked… CONTINUE READING

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