Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein.

@article{Dupuis1999ModulationO5,
  title={Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein.},
  author={Delphine S. Dupuis and St{\'e}phanie Tardif and Thierry Wurch and F. C. Colpaert and Petrus Johan Pauwels},
  journal={Neuropharmacology},
  year={1999},
  volume={38 7},
  pages={1035-41}
}
The activity state of G proteins is involved in the ligands' maximal responses that can be produced by activating the 5-HT1A receptor (Pauwels et al., 1997). The present study investigated the ligand responses at the recombinant h 5-HT1A receptor (RC: 2.1.5HT.01A) as mediated by the Galpha(o) protein. Therefore, a fusion protein was constructed between the 5-HT1A receptor and a pertussis toxin resistant rat Galpha(o)Cys351Gly mutant protein to define its pharmacological properties at a receptor… CONTINUE READING
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