• Medicine
  • Published in
    Pharmacology, biochemistry…
    2001

Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

@article{Vickers2001ModulationO5,
  title={Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.},
  author={Steven P. Vickers and Neil Easton and C. S. Malcolm and N. H. Allen and Richard H. P. Porter and Michael J Bickerdike and Guy A. Kennett},
  journal={Pharmacology, biochemistry, and behavior},
  year={2001},
  volume={69 3-4},
  pages={
          643-52
        }
}
The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)(2C) receptor agonists was investigated in vivo and in vitro at rat 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. The 5-HT(2C) receptor agonist, (S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine fumarate (Ro 60-0175), did not induce a significant head-twitch response when given alone, yet when administered to rats subsequent to an acute challenge with the selective 5-HT(2C) receptor antagonist, 6-chloro-5-methyl-1-[6-(2… CONTINUE READING

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