Modulation of 5-HT(1A) receptor-mediated Ca(2+) responses by co-expression with various recombinant G(alpha) proteins in CHO-K1 cells.

Abstract

The ability of the human 5-HT(1A) receptor to activate different recombinant G(alpha) proteins was investigated in CHO-K1 cells by monitoring 5-HT ligand-mediated Ca(2+) responses upon co-expression with either G(alphaq), G(alpha15) or chimeric G(alphaq/i3) proteins. Each G(alpha) protein yielded a typical 5-HT-dependent Ca(2+) response with different… (More)

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