Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes.

@article{Castonguay1991ModulationO4,
  title={Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes.},
  author={Andr{\'e} Castonguay and P Pepin and Normand Bri{\`e}re},
  journal={Cancer letters},
  year={1991},
  volume={59 1},
  pages={67-74}
}
The nicotine-derived N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone (NNK) is abundant in tobacco smoke and is a potent carcinogen in laboratory animals. We have characterized and compared methyl hydroxylation leading to formaldehyde formation (activation pathway) and denitrosation (putative deactivation pathway) of NNK using rat liver… CONTINUE READING