Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2.

@article{Totta2016ModulationO1,
  title={Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2.},
  author={Pierangela Totta and Fabio Gionfra and Claudia Busonero and Filippo Acconcia},
  journal={Journal of cellular physiology},
  year={2016},
  volume={231 6},
  pages={1219-25}
}
The sex hormone 17β-estradiol (E2) exerts pleiotropic effects by binding to the ligand-activated transcription factor estrogen receptor α (ERα). The E2:ERα complex regulates several physiological processes, including cell survival and proliferation, through transcriptional effects (i.e., estrogen responsive element [ERE]-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., the activation of extra-nuclear signaling cascades), which derive from the activation of the… CONTINUE READING