Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension

  title={Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension},
  author={Ram{\'o}n Rodrigo and Andr{\'e}s Miranda-Merchak and Rodrigo Valenzuela Grau and Juan P Bachler and Leonardo Vergara},
  journal={Clinical and Experimental Hypertension},
  pages={17 - 26}
Abstract Oxidative stress (OS) plays a key role in the pathophysiology of essential hypertension and is associated with changes in the cell membrane fatty acid composition and fluidity. As (Na,K)-ATPase is modulated by the surrounding lipid microenvironment, lipid peroxidation could alter the interactions of this enzyme with the membrane components. Thus, modifications in the membrane fatty acid profile will translate into effects on (Na,K)-ATPase activity. Accordingly, a decrease in this… 
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