Corpus ID: 40780566

Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations.

@article{Basile1992ModulationO,
  title={Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations.},
  author={Anthony S. Basile and Ian A. Paul and A Mirchevich and Gemma A. J. Kuijpers and B de Costa},
  journal={Molecular pharmacology},
  year={1992},
  volume={42 5},
  pages={
          882-9
        }
}
The ability of cations to modulate the binding of the sigma 1 receptor-selective ligand (+)-[3H]pentazocine to guinea pig cerebellum was investigated. Di- and trivalent cations biphasically inhibited (+)-[3H]pentazocine binding, revealing multiple affinity states. The rank order of potency of these cations (based on the high affinity component of inhibition) was Zn2+ > Co2+ >> La3+ = Ni2+ = Cd2+ = Mn2+ = Gd2+ > Ba2+ = Sr2+ >> Mg2+ > Ca2+. The inhibition of 1,3-[3H]di(2-tolyl)guanidine binding… Expand
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