Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal.

@article{Kim2013ModulationO,
  title={Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal.},
  author={Hoon Il Kim and Jun Wu and Shoudong Ye and Chih-I Tai and Xingliang Zhou and Hexin Yan and Ping Li and Martin Pera and Qi-Long Ying},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2403}
}
Wnt/β-catenin signalling has a variety of roles in regulating stem cell fates. Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understood. Here we show that Wnt/β-catenin functions in both self-renewal and differentiation in mouse epiblast stem cells. Stabilization and nuclear translocation of β-catenin and its subsequent binding to T-cell factors induces differentiation. Conversely, retention of stabilized β-catenin in the cytoplasm maintains self-renewal… CONTINUE READING
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Wnt/beta-catenin signalling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

  • Davidson, C K.
  • Proc. Natl Acad. Sci. USA
  • 2012

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

  • D ten Berge
  • Nat. Cell Biol
  • 2011

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