Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents

@article{Mcauley1993ModulationO,
  title={Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents},
  author={J. Mcauley and P. Kroboth and D. Stiff and I. Reynolds},
  journal={Pharmacology Biochemistry and Behavior},
  year={1993},
  volume={45},
  pages={77-83}
}
Progesterone is metabolized by ring-A reduction with subsequent oxidoreduction to 3 alpha-hydroxy-5 alpha-dihydroprogesterone (3 alpha-OH-5 alpha-DHP), a naturally occurring metabolite that has been shown to enhance [3H]flunitrazepam ([3H]FNZ) binding. Medroxyprogesterone acetate (MPA), a commonly prescribed progestational agent, is a synthetic progesterone derivative that has a metabolic profile similar to that of progesterone. In this study, the effects of MPA and its ring-A reduced… Expand
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