Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents.

  title={Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents.},
  author={James W Mcauley and Patricia Dowley Kroboth and Dwight D. Stiff and Ian J. Reynolds},
  journal={Pharmacology, biochemistry, and behavior},
  volume={45 1},
Progesterone is metabolized by ring-A reduction with subsequent oxidoreduction to 3 alpha-hydroxy-5 alpha-dihydroprogesterone (3 alpha-OH-5 alpha-DHP), a naturally occurring metabolite that has been shown to enhance [3H]flunitrazepam ([3H]FNZ) binding. Medroxyprogesterone acetate (MPA), a commonly prescribed progestational agent, is a synthetic progesterone derivative that has a metabolic profile similar to that of progesterone. In this study, the effects of MPA and its ring-A reduced… CONTINUE READING