Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects.

Abstract

BACKGROUND Phosphoinositide 3-kinase (PI3-K) signaling plays a crucial role in neuronal growth and plasticity. Recently, we demonstrated that suicide brain is associated with decreased activation and expression of selective catalytic and regulatory subunits of PI3-K. The present investigation examined the regulation and functional significance of… (More)
DOI: 10.1016/j.biopsych.2009.12.031

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@article{Dwivedi2010ModulationIA, title={Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects.}, author={Yogesh Dwivedi and Hooriyah S. Rizavi and Hui Zhang and Rosalinda C. Roberts and Robert R. Conley and G. N. Pandey}, journal={Biological psychiatry}, year={2010}, volume={67 11}, pages={1017-25} }