Modulation by peripheral opioids of basal and distension‐stimulated gastric acid secretion in the rat

  title={Modulation by peripheral opioids of basal and distension‐stimulated gastric acid secretion in the rat},
  author={J. Esplugues and M. Barrachina},
  journal={British Journal of Pharmacology},
1 The influence of opioids in modulating gastric acid secretory responses has been investigated in the continuously perfused stomach of the anaesthetized rat. 2 Intravenous administration of morphine (0.75–3 mg kg−1) or the peripherally acting enkephalin analogue, BW443C (0.75–3 mg kg−1), substantially augmented acid secretion in basal conditions. These effects were significantly inhibited by the opioid antagonists naloxone (1 mg kg−1) and the peripherally acting N‐methylnalorphine (2 mg kg−1… Expand
Endotoxin inhibition of distension‐stimulated gastric acid secretion in rat: mediation by NO in the central nervous system
The present results imply the existence of an acute response to endotoxin involving NO synthesis in the brain, which may act as a neuromodulator or neurotransmitter in a nervous reflex leading to the inhibition of acid secretion stimulated by gastric distension. Expand
Role of central oxytocin in the inhibition by endotoxin of distension-stimulated gastric acid secretion
A role for the endogenous release and action in the central nervous system of oxytocin in the inhibitory effect of endotoxin on gastric acid secretion is supported. Expand
The role of peripheral opioid receptor subtypes in the modulation of gastric acid secretion and plasma gastrin in dogs.
The peripheral opioid receptor subtypes involved in the regulation of gastric acid secretion were studied in dogs with both a gastric fistula and a Heidenhain pouch, by using the putative mu-opioidExpand
Nitric oxide donors preferentially inhibit neuronally mediated rat gastric acid secretion.
It is suggested that NO does not directly influence acid secretion in vivo but could play an inhibitory modulator role in neuronally mediated acid responses, as induced by gastric distension or i.v. bolus administration. Expand
Effect of endomorphin on somatostatin secretion in the isolated perfused rat stomach
Application of the specific mu-opiate receptor antagonist CTOP in doses of 10(-7) to 10(-5) M significantly attenuated the inhibitory effect of EM-1 and naloxone 10(-6) M completely abolished the inhibitor effect ofEM-1 10 (-7) M. Expand
Effects of Endotoxin on Neurally‐mediated Gastric Acid Secretion in the Rat
The effects of a peripheral administration of E. coli endotoxin on neurally‐mediated gastric acid secretion and the role of endogenous opioids or PAF receptors in endotoxin effects have beenExpand
Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.
The neurochemical coding of MOR-positive enteric neurons in the guinea pig gut is identified and differential trafficking of MOR in these neurons in response to established and putative MOR agonists is demonstrated. Expand
Bedeutung von exogenem Endomorphin-1, Endomorphin-2 und Nociceptin/Orphanin FQ für die Regulation der Somatostatinsekretion am isoliert perfundierten Rattenmagen
Am isoliert perfundierten Rattenmagen wurde die Bedeutung von exogenem Endomorphin-1, Endomorphin-2 und N/OFQ (Nociceptin/Orphanin FQ) auf die Somatostatinsekretion untersucht. Dabei hat sichExpand


Morphine inhibits the gastric acid secretion stimulated by 2-deoxy-D-glucose via a central mechanism in anesthetized rats.
Observations indicate that morphine suppressed the 2-DG-induced gastric acid secretion via a central mechanism(s), probably mediated by the opiate receptor(s). Expand
Local opioid‐sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf
Results indicate that peripheral opiate‐sensitive afferent sensory neurones play a physiological defensive role in the mucosa, attenuating the extent of gastric damage induced by Paf. Expand
Morphine reduces vagal-stimulated gastric acid secretion through a central action.
It is suggested that morphine inhibits vagal-stimulated gastric acid secretion in rats by acting predominantly on opioid receptors in the central nervous system. Expand
Effects of morphine and naloxone on stress ulcer formation and gastric acid secretion.
The data suggest that central and/or peripheral opiate receptors can modulate both basal and stress-perturbed gastric function, and that chronic naloxone-treated groups exhibited markedly enhanced gastric secretion. Expand
Influence of capsaicin‐sensitive afferent neurones on the acid secretory responses of the rat stomach in vivo
Observations indicate that peripheral capsaicin‐sensitive sensory neurones, located both in the gastric mucosa and in the coeliac ganglion, play a physiological role in the acid secretory responses to gastric distension. Expand
Morphine potentiation of ethanol-induced gastric mucosal damage in the rat. Role of local sensory afferent neurons.
A pathophysiological role for activation of local opioid-sensitive afferent neurons in the modulation of mucosal injury following challenge is supported, suggesting actions on a common mechanism. Expand
Methadone inhibition of vagally induced pancreatic and gastric secretions in rats: central and peripheral sites of action.
It is concluded that methadone inhibits vagal stimulation of digestive secretions by acting both centrally and peripherally (probably by inhibiting the release of acetylcholine from vagal fibers). Expand
Effects of naloxone on basal and vagus nerve-induced secretions of GRP, gastrin, and somatostatin from the isolated perfused rat stomach.
The findings suggest that basal somatostatin secretion is under the control of an opiate neuron and that opioid peptides might be involved in vagal regulation of GRP and gastrin secretion. Expand
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
  • D. A. Fox, T. Burks
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1988
The opioid receptors involved in the mediation of gastric acid secretory effects were studied in the pylorus-ligated rat and morphine was found to be a central site of action for morphine. Expand
Effects of morphine, hypoxaemia and hypercapnia on the rat stomach.
It is suggested that the effect of morphine on gastric acid secretion may result from its respiratory depressant action and consequent acute stress production, however, the mechanisms by which morphine can increase mucus synthesis and produce ulceration remain obscure. Expand