Modulation by peripheral opioids of basal and distension‐stimulated gastric acid secretion in the rat

@article{Esplugues1992ModulationBP,
  title={Modulation by peripheral opioids of basal and distension‐stimulated gastric acid secretion in the rat},
  author={J. Esplugues and M. Barrachina},
  journal={British Journal of Pharmacology},
  year={1992},
  volume={106}
}
1 The influence of opioids in modulating gastric acid secretory responses has been investigated in the continuously perfused stomach of the anaesthetized rat. 2 Intravenous administration of morphine (0.75–3 mg kg−1) or the peripherally acting enkephalin analogue, BW443C (0.75–3 mg kg−1), substantially augmented acid secretion in basal conditions. These effects were significantly inhibited by the opioid antagonists naloxone (1 mg kg−1) and the peripherally acting N‐methylnalorphine (2 mg kg−1… Expand
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