Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells.

@article{Robello1994ModulationBE,
  title={Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells.},
  author={Mauro Robello and Pietro Baldelli and Aroldo Cupello},
  journal={Neuroscience},
  year={1994},
  volume={61 4},
  pages={833-7}
}
The Cl- currents activated by GABA via GABAA receptors in rat cerebellum granule cells in culture were studied by whole-cell patch-clamp. These currents were measured at various extracellular pH. The currents activated by 100 microM GABA, both the peak and the steady-state component, increase at acidic pH's and decrease at basic pH's. The transition point being at around 7.7. Interestingly, passing from pH 7.4 to 6.4 the GABA dose-response curve indicates that the increases in the peak current… CONTINUE READING

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