Modulation by conagenin of inflammatory mediator productions in mice given 5-fluorouracil.


The effect of conagenin (CNG) on the production of the inflammatory mediators induced by 5-fluorouracil (5-Fu) in mice was investigated. We found that the production of interleukin (IL)-1 alpha and prostaglandin E2(PGE2) in whole spleen cell cultures from mice given a sublethal dose of 5-Fu was induced in the week after treatment, and subsequently the… (More)


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