Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices.

@article{Ross1998ModulationBA,
  title={Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices.},
  author={F M Ross and Martin J Brodie and Trevor W Stone},
  journal={British journal of pharmacology},
  year={1998},
  volume={123 1},
  pages={71-80}
}
1. Hippocampal slices (450 microm) generate epileptiform bursts of an interictal nature when perfused with a zero magnesium medium containing 4-aminopyridine (50 microM). The effect of adenine nucleotides on this activity was investigated. 2. ATP and adenosine depressed this epileptiform activity in a concentration-dependent manner, with both purines being equipotent at concentrations above 10 microM. 3. Adenosine deaminase 0.2 u ml(-1), a concentration that annuls the effect of adenosine (50… CONTINUE READING

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