Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

  title={Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein},
  author={Branimir Sikic and G. A. Fisher and Bert L. Lum and J Jason Halsey and Lidija Beketi{\'c}-Ore{\vs}kovi{\'c} and Gang Chen},
  journal={Cancer Chemotherapy and Pharmacology},
 Intrinsic and acquired multidrug resistance (MDR) in many human cancers may be due to expression of the multidrug transporter P-glycoprotein (Pgp), which is encoded by the mdr1 gene. There is substantial evidence that Pgp is expressed both as an acquired mechanism (e.g., in leukemias, lymphomas, myeloma, and breast and ovarian carcinomas) and constitutively (e.g., in colorectal and renal cancers) and that its expression is of prognostic significance in many types of cancer. Clinical trials of… CONTINUE READING
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